Bioanalysis of Small Molecules

We offer bioanalytical method development and validation of innovative small molecules by mass spectrometry. We have the experience of being the selected partner for different companies for the development of proprietary methods from the start-up of a project to the market.

  • research: in vitro and in vivo ADMET studies  
  • early development: preliminar pharmacokinetics
  • regulatory preclinical in different species: toxicokinetics, phramacokinetics, pharmacodynamics
  • phase I studies: pharmacokinetics, dose searching studies, single and repeated dose
  • phase II to IV clinical studies: related biomarkers, interaction with concomitant medication and feed

We have a high capacity of sample processing up to 10.000 per month. 

Moreover, KYMOS also provides pharmacokinetic data analysis and statistics using WinNonlin® and pharmacokinetic final report writing. All the activities can be performed under GLP when required.

Added value thanks to...

  • Experience in challenging methods: peptides, hormones, low limits of quantification, unstable compounds, different metabolites by using the same method.
  • Capability to work with polysaccharides.
  • Possibility to face dual methods in the same study: HPLC-MS/MS  for small molecules and ELISA (or other immunoassay) for biomarker proteins involved
  • Available technology for organometalic compounds: AAS and ICP/MS.
  • Fulfilment of the requirements to import and use narcotic and psycotrophic drugs.
  • Laboratory prepared to manage high potency drugs

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