Bioanalysis of Small Molecules

We can develop and validate bioanalytical methods for innovative small molecules using mass spectrometry. We have the experience that comes from being the partner selected by several companies to develop of proprietary methods from project kick-off to market.

  • Research: in vitro and in vivo ADMET studies  
  • Early development: preliminary pharmacokinetics
  • Regulatory preclinical in different species: toxicokinetics, pharmacokinetics, pharmacodynamics
  • Phase I studies: pharmacokinetics, dose searching studies, single and repeated dose
  • Phase II to IV clinical studies: related biomarkers, interaction with concomitant medication and feed

We have a great capacity for processing samples, up to 10.000 per month.

Moreover, KYMOS also provides pharmacokinetic data analysis and statistics using WinNonlin® and pharmacokinetic final report writing. All the activities can be performed under GLP when required.


Added value thanks to...

  • Experience in challenging methods: peptides, hormones, low limits of quantification, unstable compounds, different metabolites by using the same method.
  • Capability to work with polysaccharides.
  • Possibility to face dual methods in the same study: HPLC-MS/MS  for small molecules and ELISA (or other immunoassay) for biomarker proteins involved
  • Available technology for organometalic compounds: AAS and ICP/MS.
  • Fulfilment of the requirements to import and use narcotic and psycotrophic drugs.
  • Laboratory prepared to manage high potency drugs

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