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15Jun18

KYMOS communication at Waters Farma Forum

KYMOS presented an oral contribution at Waters Farma Forum held past 14 June 2018 in Barcelona. Kymos' Biologics Scientific Director, Dr. Carles Celma, shared with the attendees some studies related to the characterization of recombinant proteins. In the talk was discussed about the application of the liquid chromatography coupled to the high resolution tandem mass spectrometry (LC-HR-MS/MS) to the characterization of the primary structure of recombinant proteins. It was described the sequence confirmation and post-translational modifications of a therapeutic monoclonal antibody (mAb) by peptide mapping and molecular mass determination of the entire molecule. Also, it was presented the application of this technique to determine the number and position of the toxin drug in an antibody drug conjugate (ADC)

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