Kymos has recently acquired a new Waters Xevo G2-S QTof Mass Spectrometer in order to enhance its capabilities in protein characterization. This instrument has an extremely high sensitivity, a mass range up to 100 000 D and a resolving power of >32 500 (FWHM). In addition, Kymos has also acquired the BiopharmaLynx and MaxEnt software to improve the data processing for molecular weight determination and sequencing of proteins. This QTof is coupled to an Acquity UPLC H-Class Bio, especially designed to work with biological products. The main added value of this new equipment is to provide high capacity of sequencing proteins, to study postraductional modifications and to compare batch to batch changes in the amino acid sequence of therapeutic proteins.